Donor Screening

Infectious Disease Testing

Each donor must also complete an accompanying Medical Social Questionnaire (MSQ) with each Infectious Disease Testing (IDT). The IDT covers the following tests:

  • Chlamydia trachomatis (C. trachomatis)
  • Cytomegalovirus Antibodies (Total Antibody)
  • Cytomegalovirus Antibodies (IgM fraction)
  • HBV
  • Hepatitis B Surface Antigen (HBsAg)
  • Hepatitis B Core Antibody (HBcAb; HBc IgG-IgM)
  • Hepatitis C Virus Antibody (HCV)
  • HIV-1 / HCV / H / HBV NAT
  • Human Immunodeficiency Virus 1, O, and 2 (HIV 1/O/2)
  • Human T-Cell Lymphotropic Virus-I / II (HTLV-I / II)
  • Neisseria gonorrhea (N. gonorrhea)
  • Syphilis serology (Treponema pallidum)
  • West Nile Virus NAT


Non-Infectious Disease Testing

Non-infectious analyses are also performed on all Cryobank America Donors. The types of analyses in the blood chemistry profile include:

  • Albumin
  • Alkaline Phosphatase
  • Alanine Aminotransferase (ALT)
  • Aspartate Aminotransferase (AST)
  • Calcium
  • Cholesterol (HDL, LDL, VLDL)
  • Creatinine
  • Glucose
  • Lactate Dehydrogenase (LDH)
  • Iron (Total Fe, Fe Binding, % Saturation)
  • Triglycerides
  • Total Bilirubin
  • Total Protein
  • Urea Nitrogen
  • Uric Acid


Complete Blood Count

The following parameters are evaluated in the Completed Blood Count:

  • Cell morphology
  • Hematocrit
  • Hemoglobin
  • Mean Corpuscular Hemoglobin (MCH)
  • Mean Corpuscular Hemoglobin Concentration (MCHC)
  • Mean Corpuscular Volume (MCV)
  • Mean Platelet Volume (MPV)
  • Microscopic examination of Basos
  • Eos
  • Lymphs
  • Polys
  • Red Blood
  • Platelet Screen
  • Red Blood Cell (RBC) Count
  • White Blood Cell (WBC) Count



CA Donors will also undergo routine urinalyses, which is used to screen for the general health of a donor’s urinary tract system.

The following parameters are evaluated with the urinalysis:

    • Bilirubin
    • Clarity
    • Color
  • Glucose
  • Ketones
  • Leukocyte esterase
  • pH
  • Protein
  • Microscopic evaluation for squamous cells
  • Casts
  • Crystals


Drug Testing and Criminal History Background Check

Drug use has been known to affect the potency of motile sperm, therefore in addition to the testing performed above, Cryobank America performs criminal background checks and drug testing on all donors to provide the highest quality products to our clients.


Psychiatric Evaluation (a Cryobank America Exclusive!)

As part of joining the Cryobank America Sperm Donor Program, each donor will visit a psychiatrist and undergo a full mental health evaluation and counseling


Chromosome Analysis

Also known as Karyotyping, this analysis is used to detect chromosome abnormalities, which can help uncover and diagnose hidden genetic diseases, birth defects, and certain disorders of the blood and lymphatic system. All Cryobank America donors undergo Chromosome Analysis testing.


Counsyl Genetic Screening

Every Cryobank America donor will have genetic carrier screening performed by Counsyl, a CLIA regulated testing facility.Genetic diseases that Cryobank America Donors undergo include testing for: