Infectious Disease Testing
Each donor must also complete an accompanying Medical Social Questionnaire (MSQ) with each Infectious Disease Testing (IDT). The IDT covers the following tests:
- Chlamydia trachomatis (C. trachomatis)
- Cytomegalovirus Antibodies (Total Antibody)
- Cytomegalovirus Antibodies (IgM fraction)
- HBV
- Hepatitis B Surface Antigen (HBsAg)
- Hepatitis B Core Antibody (HBcAb; HBc IgG-IgM)
- Hepatitis C Virus Antibody (HCV)
- HIV-1 / HCV / H / HBV NAT
- Human Immunodeficiency Virus 1, O, and 2 (HIV 1/O/2)
- Human T-Cell Lymphotropic Virus-I / II (HTLV-I / II)
- Neisseria gonorrhea (N. gonorrhea)
- Syphilis serology (Treponema pallidum)
- West Nile Virus NAT
Non-Infectious Disease Testing
Non-infectious analyses are also performed on all Cryobank America Donors. The types of analyses in the blood chemistry profile include:
- Albumin
- Alkaline Phosphatase
- Alanine Aminotransferase (ALT)
- Aspartate Aminotransferase (AST)
- Calcium
- Cholesterol (HDL, LDL, VLDL)
- Creatinine
- Glucose
- Lactate Dehydrogenase (LDH)
- Iron (Total Fe, Fe Binding, % Saturation)
- Triglycerides
- Total Bilirubin
- Total Protein
- Urea Nitrogen
- Uric Acid
Complete Blood Count
The following parameters are evaluated in the Completed Blood Count:
- Cell morphology
- Hematocrit
- Hemoglobin
- Mean Corpuscular Hemoglobin (MCH)
- Mean Corpuscular Hemoglobin Concentration (MCHC)
- Mean Corpuscular Volume (MCV)
- Mean Platelet Volume (MPV)
- Microscopic examination of Basos
- Eos
- Lymphs
- Polys
- Red Blood
- Platelet Screen
- Red Blood Cell (RBC) Count
- White Blood Cell (WBC) Count
Urinalysis
CA Donors will also undergo routine urinalyses, which is used to screen for the general health of a donor’s urinary tract system.
The following parameters are evaluated with the urinalysis:
-
- Bilirubin
- Clarity
- Color
- Glucose
- Ketones
- Leukocyte esterase
- pH
- Protein
- Microscopic evaluation for squamous cells
- Casts
- Crystals
Drug Testing and Criminal History Background Check
Psychiatric Evaluation (a Cryobank America Exclusive!)
Chromosome Analysis
Also known as Karyotyping, this analysis is used to detect chromosome abnormalities, which can help uncover and diagnose hidden genetic diseases, birth defects, and certain disorders of the blood and lymphatic system. All Cryobank America donors undergo Chromosome Analysis testing.
Counsyl Genetic Screening
Every Cryobank America donor will have genetic carrier screening performed by Counsyl, a CLIA regulated testing facility.Genetic diseases that Cryobank America Donors undergo include testing for:
- 11-beta-hydroxylase-deficient Congenital Adrenal Hyperplasia
- 21-hydroxylase-deficient Congenital Adrenal Hyperplasia
- 6-pyruvoyl-tetrahydropterin Synthase Deficiency
- ABCC8-related Hyperinsulinism
- Adenosine Deaminase Deficiency
- Alpha Thalassemia
- Alpha-mannosidosis
- Alpha-sarcoglycanopathy
- Alstrom Syndrome
- AMT-related Glycine Encephalopathy
- Andermann Syndrome
- Argininemia
- Argininosuccinic Aciduria
- ARSACS
- Aspartylglycosaminuria
- Ataxia with Vitamin E Deficiency
- Ataxia-telangiectasia
- ATP7A-related Disorders
- Autosomal Recessive Osteopetrosis Type 1
- Bardet-Biedl Syndrome, BBS1-related
- Bardet-Biedl Syndrome, BBS10-related
- Bardet-Biedl Syndrome, BBS12-related
- Bardet-Biedl Syndrome, BBS2-related
- Beta-sarcoglycanopathy
- Biotinidase Deficiency
- Bloom Syndrome
- Calpainopathy
- Canavan Disease
- Carbamoylphosphate Synthetase I Deficiency
- Carnitine Palmitoyltransferase IA Deficiency
- Carnitine Palmitoyltransferase II Deficiency
- Cartilage-hair Hypoplasia
- Cerebrotendinous Xanthomatosis
- Citrullinemia Type 1
- CLN3-related Neuronal Ceroid Lipofuscinosis
- CLN5-related Neuronal Ceroid Lipofuscinosis
- CLN6-related Neuronal Ceroid Lipofuscinosis
- Cohen Syndrome
- COL4A3-related Alport Syndrome
- COL4A4-related Alport Syndrome
- Congenital Disorder of Glycosylation Type Ia
- Congenital Disorder of Glycosylation Type Ib
- Congenital Disorder of Glycosylation Type Ic
- Congenital Finnish Nephrosis
- Costeff Optic Atrophy Syndrome
- Cystic Fibrosis
- Cystinosis
- D-bifunctional Protein Deficiency
- Delta-sarcoglycanopathy
- Dysferlinopathy
- Dystrophinopathy (Including Duchenne/Becker Muscular Dystrophy)
- ERCC6-related Disorders
- ERCC8-related Disorders
- EVC-related Ellis-van Creveld Syndrome
- EVC2-related Ellis-van Creveld Syndrome
- Fabry Disease
- Familial Dysautonomia
- Familial Mediterranean Fever
- Fanconi Anemia Complementation Group A
- Fanconi Anemia Type C
- FKRP-related Disorders
- FKTN-related Disorders
- Fragile X Syndrome
- Galactokinase Deficiency
- Galactosemia
- Gamma-sarcoglycanopathy
- Gaucher Disease
- GJB2-related DFNB1 Nonsyndromic Hearing Loss and Deafness
- GLB1-related Disorders
- GLDC-related Glycine Encephalopathy
- Glutaric Acidemia Type 1
- Glycogen Storage Disease Type Ia
- Glycogen Storage Disease Type Ib
- Glycogen Storage Disease Type III
- GNPTAB-related Disorders
- GRACILE Syndrome
- HADHA-related Disorders
- Hb Beta Chain-related Hemoglobinopathy (Including Beta Thalassemia and Sickle Cell Disease)
- Hereditary Fructose Intolerance
- Herlitz Junctional Epidermolysis Bullosa, LAMA3-related
- Herlitz Junctional Epidermolysis Bullosa, LAMB3-related
- Herlitz Junctional Epidermolysis Bullosa, LAMC2-related
- Hexosaminidase A Deficiency (Including Tay-Sachs Disease)
- HMG-CoA Lyase Deficiency
- Holocarboxylase Synthetase Deficiency
- Homocystinuria Caused by Cystathionine Beta-synthase Deficiency
- Hydrolethalus Syndrome
- Hypophosphatasia, Autosomal Recessive
- Inclusion Body Myopathy 2
- Isovaleric Acidemia
- Joubert Syndrome 2
- KCNJ11-related Familial Hyperinsulinism
- Krabbe Disease
- LAMA2-related Muscular Dystrophy
- Leigh Syndrome, French-Canadian Type
- Lipoamide Dehydrogenase Deficiency
- Lipoid Congenital Adrenal Hyperplasia
- Lysosomal Acid Lipase Deficiency
- Maple Syrup Urine Disease Type 1B
- Maple Syrup Urine Disease Type Ia
- Maple Syrup Urine Disease Type II
- Medium Chain Acyl-CoA Dehydrogenase Deficiency
- Megalencephalic Leukoencephalopathy with Subcortical Cysts
- Metachromatic Leukodystrophy
- Methylmalonic Acidemia, cblA Type
- Methylmalonic Acidemia, cblB Type
- Methylmalonic Aciduria and Homocystinuria, cblC Type
- MKS1-related Disorders
- Mucolipidosis III Gamma
- Mucolipidosis IV
- Mucopolysaccharidosis Type I
- Mucopolysaccharidosis Type II
- Mucopolysaccharidosis Type IIIA
- Mucopolysaccharidosis Type IIIB
- Mucopolysaccharidosis Type IIIC
- Muscle-eye-brain Disease
- MUT-related Methylmalonic Acidemia
- MYO7A-related Disorders
- NEB-related Nemaline Myopathy
- Niemann-Pick Disease Type C
- Niemann-Pick Disease Type C2
- Niemann-Pick Disease, SMPD1-associated
- Nijmegen Breakage Syndrome
- Northern Epilepsy
- Ornithine Transcarbamylase Deficiency
- PCCA-related Propionic Acidemia
- PCCB-related Propionic Acidemia
- PCDH15-related Disorders
- Pendred Syndrome
- Peroxisome Biogenesis Disorder Type 3
- Peroxisome Biogenesis Disorder Type 4
- Peroxisome Biogenesis Disorder Type 5
- Peroxisome Biogenesis Disorder Type 6
- PEX1-related Zellweger Syndrome Spectrum
- Phenylalanine Hydroxylase Deficiency
- PKHD1-related Autosomal Recessive Polycystic Kidney Disease
- Polyglandular Autoimmune Syndrome Type 1
- Pompe Disease
- PPT1-related Neuronal Ceroid Lipofuscinosis
- Primary Carnitine Deficiency
- Primary Hyperoxaluria Type 1
- Primary Hyperoxaluria Type 2
- Primary Hyperoxaluria Type 3
- PROP1-related Combined Pituitary Hormone Deficiency
- Pycnodysostosis
- Pyruvate Carboxylase Deficiency
- Rhizomelic Chondrodysplasia Punctata Type 1
- RTEL1-related Disorders
- Salla Disease
- Sandhoff Disease
- Segawa Syndrome
- Short Chain Acyl-CoA Dehydrogenase Deficiency
- Sjogren-Larsson Syndrome
- Smith-Lemli-Opitz Syndrome
- Spastic Paraplegia Type 15
- Spinal Muscular Atrophy
- Spondylothoracic Dysostosis
- Steroid-resistant Nephrotic Syndrome
- Sulfate Transporter-related Osteochondrodysplasia
- TGM1-related Autosomal Recessive Congenital Ichthyosis
- TPP1-related Neuronal Ceroid Lipofuscinosis
- Tyrosinemia Type I
- Tyrosinemia Type II
- USH1C-related Disorders
- USH2A-related Disorders
- Usher Syndrome Type 3
- Very Long Chain Acyl-CoA Dehydrogenase Deficiency
- Wilson Disease
- X-linked Adrenoleukodystrophy
- X-linked Alport Syndrome
- X-linked Congenital Adrenal Hypoplasia
- X-linked Juvenile Retinoschisis
- X-linked Myotubular Myopathy
- X-linked Severe Combined Immunodeficiency
- Xeroderma Pigmentosum Group A
- Xeroderma Pigmentosum Group C