What is CMV?

CMV stands for cytomegalovirus. It is a virus that can be transmitted to a developing fetus before birth. It is a member of the herpes family of viruses that include mono and chickenpox. The CDC states that nearly 1 in 3 children have already been infected with CMV by age 5, and by the age of 40, over half of the population is infected.

Primary CMV infection occurs in people who have never been exposed to the CMV virus before. Once a person becomes infected with CMV, the virus remains alive but dormant inside their body for the rest of their life. Recurrent CMV infection is when a dormant virus becomes active again. CMV infection is usually harmless and rarely causes illness. However, primary CMV infection can cause more severe problems for pregnant women than recurrent CMV infection.

CMV and Using a CMV Donor:

The FDA requires CMV testing on all men who intend to donate sperm. A positive result, however, doesn’t necessarily mean that a man will be ineligible to donate. Cryobank America will obtain semen samples from potential donors and then quarantine those specimens for at least six months. During that time, the man may have had CMV antibody levels tested several times. If the antibody tests indicate the possibility of a CMV infection close to the time of the sperm donation, the man will not be allowed to donate those specimens. If the testing is uncertain, those men will not be permitted to donate those specimens. However, if a donor tests positive for CMV IgG only, indicating a past infection, he will be allowed to contribute. These samples are labeled in the Cryobank America database as CMV-positive.

Recommendations:

A woman considering pregnancy with donor semen should have CMV antibody testing as part of their IDT. Those with a past infection are at low risk of transmitting CMV infection to a fetus and are at little to no risk if they decide to use a CMV-positive donor. Women never exposed to CMV should consider using a CMV-negative donor. Even though the risk from a CMV-positive donor is low, it is impossible to determine whether there will be a risk for infection.

For additional information on CMV, this link is especially helpful:

https://www.mayoclinic.org/diseases-conditions/cmv/symptoms-causes/syc-20355358

If you have any questions regarding CMV please contact us at [email protected] or at 817-945-8708 and we will be happy to help you out!

Different Vial Types:

If you have been curious about using sperm donors to help start your family, you may have looked at the prices of vials and noticed several different types available. What is an IUI, ICI, A.R.T., and IVF vial? This blog will let you know the differences between each one so that it can guide you in figuring out which vial is best for you.

IUI Premium Vials

IUI (Intrauterine insemination) vials undergo a "washing" procedure utilizing gradient separation methods, resulting in only the sperm and stabilizing media, making it safe for the uterus.

At Cryobank America, we guarantee 25 Million cells per milliliter (25M/ml). Each IUI vial is sold in a half-milliliter (0.5ml) unit, giving you 12.5M/ml of motile sperm cells per premium IUI vial. IUI specimens can be safely placed directly into the uterus by your treating physician because there are no "round" cells or other "junk" in them that causes cramping. These units are also ideal for at-home inseminations, where they'll be placed near the top of the vagina and cervix.

ICI Premium Vials

ICI (intracervical insemination) vials are considered "unwashed" since they have not undergone gradient separation steps, which remove the non-motile sperm cells, round cells, and other junk found in the ejaculate.

At Cryobank America, we guarantee 17 Million cells per milliliter (17M/ml). Each vial sold comprises one milliliter (1ml). ICI units are typically used for at-home insemination since these specimens cannot be placed into the uterus due to severe cramping. Some fertility clinics prefer to wash their patient's specimens in-house (usually at an additional cost to the patient); therefore, these units contain one milliliter of a specimen compared to IUI units, which are sold in half milliliter units (0.5ml). We recommend that our clients purchase IUI units since they can work for both in-clinic procedures and at-home inseminations.

IUI A.R.T. & ICI A.R.T.

A.R.T., or artificial reproductive technology, vials are lower quantity units. At Cryobank America, we guarantee 3-12 Million per half a milliliter (and 6-24 M/ml) for IUI ART and 6-24 M/ml for ICI ART units. These vials cost less since they contain fewer progressively motile sperm cells.

IUI/IVF & ICI/IVF (For IVF/ICSI)

Lastly, our IUI/IVF undergoes our wash process and is guaranteed at 0.5-2.5 Million per half (0.5) milliliter (1-5 M/ml). Our ICI/IVF vials are unwashed, guaranteeing 1-5 Million per (1) milliliter. We recommend these units for clients utilizing in-vitro fertilization or Intracytoplasmic Sperm Injection (ICSI) procedures, where only a few sperm are needed.

If you still have questions concerning vial types and differences between the classes, don't hesitate to contact one of our friendly and knowledgeable Cryobank America staff members today!

Please email us at [email protected] or give us a call at 817-945-8708

All pricing can be found at https://cryobankamerica.com/pricing/